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Iron metabolism disorder, lipid peroxidation and decreased antioxidant capacity are involved in the occurrence of ferroptosis, and several key regulators (e.g., system Xc - , GPX4, p53 and ACSL4) play an important role in monitoring ferroptosis

Levothyroxine, by optimizing thyroid function, may also indirectly benefit cardiovascular health

In summary, arginine depletion may be a feasible approach for cancer treatment because of the anti-cancer effects reported in pre-clinical studies, the low adverse reactions and the treatment-achieved stable disease in clinical trials of advanced stage cancers

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